"The reality of COVID anti-virals is that it is not enough merely to suspend viral replication. The body has to end up clear of the virus. When the body does not clear the virus, regardless of the reason why, the anti-viral fails by definition."
No no, not according to Pfizer. It wasn't Paxlovid that failed, it was the poor innate immune…
"The reality of COVID anti-virals is that it is not enough merely to suspend viral replication. The body has to end up clear of the virus. When the body does not clear the virus, regardless of the reason why, the anti-viral fails by definition."
No no, not according to Pfizer. It wasn't Paxlovid that failed, it was the poor innate immune system of the host that didn't clear it. Excellent article, I was already convinced Paxlovid was a failure (thanks to Igor and Brian), but this really hammered it home.
“Paxlovid does what it has to do: it reduces the viral load,” Chief Executive Officer Albert Bourla said in an interview. “Then your body is supposed to do the job.” But for unknown reasons, the CEO said, some patients aren’t able to clear the virus with the first course of treatment.
The most benevolent interpretation of the data is that Paxlovid does not aid in viral clearance other than suspending viral replication.
If that is inadequate to achive viral clearance, then Paxlovid does not work. It might be functioning as designed, but, as designed, it is demonstrably inadequate to the task at hand.
"The reality of COVID anti-virals is that it is not enough merely to suspend viral replication. The body has to end up clear of the virus. When the body does not clear the virus, regardless of the reason why, the anti-viral fails by definition."
No no, not according to Pfizer. It wasn't Paxlovid that failed, it was the poor innate immune system of the host that didn't clear it. Excellent article, I was already convinced Paxlovid was a failure (thanks to Igor and Brian), but this really hammered it home.
https://www.bloomberg.com/news/newsletters/2022-05-04/pfizer-s-advice-for-when-paxlovid-isn-t-enough-take-more
“Paxlovid does what it has to do: it reduces the viral load,” Chief Executive Officer Albert Bourla said in an interview. “Then your body is supposed to do the job.” But for unknown reasons, the CEO said, some patients aren’t able to clear the virus with the first course of treatment.
The most benevolent interpretation of the data is that Paxlovid does not aid in viral clearance other than suspending viral replication.
If that is inadequate to achive viral clearance, then Paxlovid does not work. It might be functioning as designed, but, as designed, it is demonstrably inadequate to the task at hand.
That's a problem. Every time.