Study Shows Omicron BA.2.75 Is Not A Threat (Maybe)

Researchers in Sweden have found that, amazingly enough, the new Omicron subvariant BA.2.75 is just as vulnerable to the existing mRNA inoculations as the original virus.

Or did they?

"Identifying how vulnerable the population is, right now, to emerging variants is crucial," says Daniel Sheward, researcher at the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, and the study's first author. "By producing a pseudovirus for BA.2.75, we were able to test its sensitivity to antibodies present in blood donors."

“Psuedovirus”? What exactly is this “psuedovirus”? Is it the BA.2.75 subvariant or not?

Short answer: it's not. From the study's “supplemental” materials.

Pseudovirus Neutralization Assay

Pseudovirus neutralization assay was performed as previously15. Briefly, spike-pseudotyped lentivirus particles were generated by co-transfection of HEK293T cells with a relevant spike plasmid, an HIV gag-pol packaging plasmid (Addgene #8455), and a lentiviral transfer plasmid encoding firefly luciferase (Addgene #170674) using polyethylenimine. The BA.2.75 spike plasmid was generated by introducing the following mutations into the BA.2 spike, by multisite directed mutagenesis: K147E, W152R, F157L, I210V, G257S G339H, G446S, N460K, R493Q, which was subsequently confirmed by sequencing.

In other words, they made up a virus and called it BA.2.75. And admit to it.

It's “research" like this that fuels the belief of many that SARS-COV-2 is all a hoax, as well as the belief that these antibody titers mean a damn thing.