Keep in mind that the historical mortality for the West African clade is reported at 3-6%, and for the Central African clade as high as 10%.
The mortality for smallpox before its eradication went as high as 30%+ in some outbreaks.
This is another example of how the public health agencies are conflating what should be properly regarded as two separate outbreaks of what are almost two different viruses--and should at the very least be regarded as different clades. The virus in the global outbreak beyond Africa has only 3 recorded deaths out of 25,000+ cases, while the West African clade in Nigeria and neighboring countries have about 5 deaths for 350 cases. The Central African clade is quite likely behind the 1500 or so suspected cases in the Central African Republic and its neighboring countries, as well as the 70 some odd deaths.
Thus the cardiac risk for Jynneos against the observed mortality of the global outbreak strain makes the vaccine not a good idea. For the West African clade it becomes a bit more problematic, and for the Central African clade a case can be made that the risk-reward benefit inures in favor of getting vaccinated.
It's also worth noting that the safety profile for Jynneos is reported to be a significant improvement over the ACAM2000 vaccine. These are, remember, first and foremost smallpox vaccines--a sufficiently dangerous pathogen that makes the risk much more easily justified. (particularly since a resurgence of smallpox at this juncture would almost certainly be an act of biological terrorism).
Question: With probably the majority of the people getting the monkey vaxx, which I have read can cause smallpox, already coof vaxxed, which lowers immunity, couldn't this cause a smallpox outbreak? Am I confusing the monkey vaxxes?
Both Jynneos and ACAM2000, the other vaccine used are both intended as smallpox vaccines, to replace the older Dryvax vaccine.
Based on observational studies from the 1980s, after smallpox vaccines were discontinued, researchers assessed that smallpox vaccines are ~85% effective against monkeypox.
While both Jynneos and ACAM2000 use the vaccinia virus, relying on the strong cross-reactive immunity to immunize against smallpox and monkeypox.
As such, it is not possible for the Jynneos vaccine to cause an outbreak of smallpox, which is the variola pathogen.
I'm no a medical guy, just an old engineer with a background in statistics, but those odds with the Jynneos shot.are horrific. There really is no upside, and ethically, such a boondoggle for doctors, everyone loses.
Keep in mind that the historical mortality for the West African clade is reported at 3-6%, and for the Central African clade as high as 10%.
The mortality for smallpox before its eradication went as high as 30%+ in some outbreaks.
This is another example of how the public health agencies are conflating what should be properly regarded as two separate outbreaks of what are almost two different viruses--and should at the very least be regarded as different clades. The virus in the global outbreak beyond Africa has only 3 recorded deaths out of 25,000+ cases, while the West African clade in Nigeria and neighboring countries have about 5 deaths for 350 cases. The Central African clade is quite likely behind the 1500 or so suspected cases in the Central African Republic and its neighboring countries, as well as the 70 some odd deaths.
Thus the cardiac risk for Jynneos against the observed mortality of the global outbreak strain makes the vaccine not a good idea. For the West African clade it becomes a bit more problematic, and for the Central African clade a case can be made that the risk-reward benefit inures in favor of getting vaccinated.
It's also worth noting that the safety profile for Jynneos is reported to be a significant improvement over the ACAM2000 vaccine. These are, remember, first and foremost smallpox vaccines--a sufficiently dangerous pathogen that makes the risk much more easily justified. (particularly since a resurgence of smallpox at this juncture would almost certainly be an act of biological terrorism).
Question: With probably the majority of the people getting the monkey vaxx, which I have read can cause smallpox, already coof vaxxed, which lowers immunity, couldn't this cause a smallpox outbreak? Am I confusing the monkey vaxxes?
Please help me understand.
Both Jynneos and ACAM2000, the other vaccine used are both intended as smallpox vaccines, to replace the older Dryvax vaccine.
Based on observational studies from the 1980s, after smallpox vaccines were discontinued, researchers assessed that smallpox vaccines are ~85% effective against monkeypox.
While both Jynneos and ACAM2000 use the vaccinia virus, relying on the strong cross-reactive immunity to immunize against smallpox and monkeypox.
As such, it is not possible for the Jynneos vaccine to cause an outbreak of smallpox, which is the variola pathogen.
Thank-you very much for answering my question! I appreciate your helping me understand.
It's my pleasure.
I'm no a medical guy, just an old engineer with a background in statistics, but those odds with the Jynneos shot.are horrific. There really is no upside, and ethically, such a boondoggle for doctors, everyone loses.
Thanks for the great work, I enjoy your posts.
Thanks!