Having deconstructed Pfizer's initial extravagant efficacy claims on their COVID-19 shot, no, we shouldn't believe those numbers. For smallpox, the claims are best guesses, because smallpox is not an endemic pathogen anywhere in the world anymore. There is no practical way to test such vaccines, since smallpox itself was eradicated decades ago.
Having deconstructed Pfizer's initial extravagant efficacy claims on their COVID-19 shot, no, we shouldn't believe those numbers. For smallpox, the claims are best guesses, because smallpox is not an endemic pathogen anywhere in the world anymore. There is no practical way to test such vaccines, since smallpox itself was eradicated decades ago.
Having deconstructed Pfizer's initial extravagant efficacy claims on their COVID-19 shot, no, we shouldn't believe those numbers. For smallpox, the claims are best guesses, because smallpox is not an endemic pathogen anywhere in the world anymore. There is no practical way to test such vaccines, since smallpox itself was eradicated decades ago.